Feeling a bit frustrated and looking for some encouragement. I am still in frontline treatment after diagnosis in February of 3c/4. I had 4 chemo and then surgery. I have had five chemo post op with Avastin added in 3 treatments ago. My CA125 has been very slow to decrease but was gradually going down. Four weeks ago it was 83.5 but today it went up to 99. This is the first increase and I am freaking out a little. I had chemo #10 today (last one). Has anyone had a minor increase during treatment but still went on to normal range eventually?