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PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

  • 1.  PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-08-2026 11:44

    Hi Teal Sisters,

    I saw this news article today about research underway at Princess Margaret Hospital (PMH) Cancer Centre in Toronto. The article doesn't list if ovarian cancer is one of the cancers being included however I'm hopeful. The trial is called SHERLOCK. The article said they were enrolled 7,000 patients. I'm not sure how they are sourcing them. Are any Teal Sisters in this forum aware or involved?

    @mfallis_OCC are you able to find able from a member of the OCC team if OVC patients are being included? 

    Is your cancer returning? A blood test might be able to tell

    CTVNews remove preview
    Is your cancer returning? A blood test might be able to tell
    Researchers at Princess Margaret Cancer Centre in Toronto are working on a large trial to determine if a blood test can detect tiny amounts of cancer remaining after patients have been treated.
    View this on CTVNews >



  • 2.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-08-2026 15:22

    Thanks, @Alwayslearning for tagging me in this post. I'll reach out to my colleagues who are connected to the research side of things and share what I can find out, as soon as possible. 




  • 3.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 09:49
    I immediately wondered whether this related to liquid biopsies (which I heard about at the recent OV cancer conference in Vancouver) and I was correct.  It would be great if OV was on the list!





  • 4.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 11:29

    Here's the link to the details of the study:

    https://clinicaltrials.gov/study/NCT07524114

    They do include gynecological cancers.  Also note the timeframes to be eligible to participate.  




  • 5.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 12:17

    Thanks @jobo for sharing. Interesting you found this on a U.S. government site. Hopefully it's also in the Canadian trials database. Guess I should have looked there. D'uh on my part. I'll take a look when I have a moment. 

    Interesting info and yes glad to see gynecological cancers are included. 




  • 6.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 12:33
    you girls should all sign up for it, if you're eligible.





  • 7.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 15:21

    Sounds similar to signatera testing, am I wrong?  Yes would be nice if we could all get on board




  • 8.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 16:13
    I've never heard of that.  





  • 9.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-09-2026 15:28

    You confirmed before I could! Thank you @jobo!

    Confirming: My colleague reviewed the information and confirmed that this study does include gynecological cancers!




  • 10.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-10-2026 11:44

    Hi, I found the information and contacted them to express my interest in participating unfortunately this research is only for patients being treated at the Princess Margaret Hospital. See message below from the research team:

    Good morning,  
      
    Thank you for your interest, please see link to our SHERLOCK website: https://www.uhn.ca/PrincessMargaret/sherlock/Pages/About.aspx  
     
    The SHERLOCK study is currently open for patients being treated at Princess Margaret Cancer Centre in Toronto Ontario, only. 
    Please consult your medical team if you have specific questions related to your case.    
      
    Best regards,  
    Sophia  
      
    Sophia Aksenchuk, RN, MN, PhD(c) 
    Clinical Nurse Specialist - Molecular Residual Disease  
    Peter Gilgan Centre for Early Cancer Detection Research 
    Princess Margaret Cancer Center, University Health Network 
    From: Yu, Celeste <Celeste.Yu@uhn.ca>
    Sent: July 10, 2026 10:59 AM
    Subject: RE: [External] Liquid Biopsy Study - Dr Lillian Siu, MD
     


    Thank you for your interest in the liquid biopsy study. I have cc'ed the SHERLOCK study team who will be able to respond to you. 

    Warm regards, 

    Celeste Yu, MSc, CCRP, PMP
    Senior Program Manager
    Cancer Genomics Program, Princess Margaret Cancer Centre
    620 University Avenue, Suite 8-203, Toronto, Ontario, M5G 2M9
    T: 416.946.4501 ext.5281 | F: 416.946.2945 | E: celeste.yu@uhn.ca



  • 11.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-11-2026 10:15

    Thank you @Dragonfly.




  • 12.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-11-2026 13:34

    @Dragonfly too bad it's only limited to pmh patients but hopefully some of you girls can get in it.




  • 13.  RE: PMH Trial SHERLOCK - Blood Test to Detect Traces of Cancer Remnants in Patients Post Treatment

    Posted 07-12-2026 14:01

    @Meinvan I am treated at PMH. I have it on my list to ask my oncologist.

    #Clinicaltrialsandresearch




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