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Hello Teal Sisters,

I recently read some information about subtypes of High Grade Serous Cancer (HGSC). Has anyone here been told which subtype you are? Are you on a modified treatment protocol as a result?

This data was published a while ago (2008) so maybe I'm just late to the table, but I've never heard of it so some of you may not have either. Links are below if you want to read a couple of papers.

I was always curious as to why some of us with the same form and stage of OC do well while others have recurrence sooner and progress faster. one possible explanation is that there are 4 subtypes of HGSC: Mesenchymal, Proliferative, Immunoreactive and Differentiated. These are the names for molecular subtypes which have differing gene expression. They correspond to four histopathological subtypes: Mesenchymal Transition, Solid and Proliferative, Immune reactive and Differentiated. The immunoreactive form has the most favorable prognosis while the mesenchymal and proliferative forms had the least. Which subtype you have can impact your response to chemo and Bevacizumab (Avastin). 

I don't have enough data in my pathology report or genetic tests to figure out which subtype I am but I have asked my oncologist if she can find out. 

Stay well,

Claire

https://doi.org/10.1186/s12885-017-3573-1

https://pmc.ncbi.nlm.nih.gov/articles/PMC8827304/

Hello Teal Sisters,

I recently read some information about subtypes of High Grade Serous Cancer (HGSC). Has anyone here been told which subtype you are? Are you on a modified treatment protocol as a result?

This data was published a while ago (2008) so maybe I'm just late to the table, but I've never heard of it so some of you may not have either. Links are below if you want to read a couple of papers.

I was always curious as to why some of us with the same form and stage of OC do well while others have recurrence sooner and progress faster. one possible explanation is that there are 4 subtypes of HGSC: Mesenchymal, Proliferative, Immunoreactive and Differentiated. These are the names for molecular subtypes which have differing gene expression. They correspond to four histopathological subtypes: Mesenchymal Transition, Solid and Proliferative, Immune reactive and Differentiated. The immunoreactive form has the most favorable prognosis while the mesenchymal and proliferative forms had the least. Which subtype you have can impact your response to chemo and Bevacizumab (Avastin). 

I don't have enough data in my pathology report or genetic tests to figure out which subtype I am but I have asked my oncologist if she can find out. 

Stay well,

Claire

https://doi.org/10.1186/s12885-017-3573-1

https://pmc.ncbi.nlm.nih.gov/articles/PMC8827304/