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ELAHERE clinical trial for platinum-sensitive Teal Sisters

I saw this on the clinical trials site and wanted to share with you. There are a lot of locations for this trial…Alberta, BC, Quebec and Ontario.

Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA)

https://clinicaltrials.gov/study/NCT05445778?

I am new to the group and saw this.
At Princess Margaret last week we were told this was not yet available in Canada.
I am there again today and will ask
Thanks for finding this information
I will try to find time to set myself up with the group.
Pat from Terra Cotta
Sent from my iPad

Hi @pat from Terra Cotta. Welcome to the OVdialogue group. The Teal Sisters here are a wealth of information, plus pretty darn good at providing virtual support when needed. When as you said, you have time, please introduce yourself and tell us your story. There's a category called "Introductions" in the drop down list at the top left of this webpage. I found the sharing very helpful when I first joined as some of my experiences resonated with others which helped make it easy to connect with them. If you have any initial questions, comments etc. either about the forum, resources available, or specific to your situation let us know that too. We are here to help each other.

If you haven't found it yet, there is an amazing Resource Guide you an download and/or order a hard copy from the OVD website. Here's a link:

https://ovariancanada.org/resources/support-resources

As an aside I too am treated at PMH. I have a wonderful medical team and have been nothing but impressed with the entire PMH medical community. I hope you will have that same experience too, especially in such a difficult time. Again, welcome. Talk soon. 

Hi @pat

Welcome to OVDialogue. This is a great place to find support and information.

You are correct…the drug is currently under review for approval for use in Canada as a standard of care drug. However, when there is a clinical trial with a drug, and the clinical trial is available in Canada and you meet trial criteria, you can participate and potentially receive the drug. 

This clinical trial is for platinum-sensitive OC only. For those of us platinum-resistant, we are anxiously awaiting approval of this drug for use in Canada.

I am also platinum resistant so will see today if there is anything to offer.
Sent from my iPad

@pat   Welcome to the group.  Thank you for sharing this information.  I am positive it may help someone at some point in time. When you do have time to introduce yourself to the group, please do so. It would be lovely to hear your story and what brought you here.  In the meantime, you can use Teal Thursdays as a way to connect with the group and tell  us where you are at in the week.  How are you and what has brought you here would be a start. That way you can connect with others going through the same thing as yourself.  Sounds like you have a busy schedule currently that prevents you from connecting with the group. Hopefully that will ease soon and you will find yourself able to connect with us soon.  I will be on the Teal Thursday this week to get us started and see where everyone is at. Hoping you can join us too.  Take care of you! 

@GloHo thank you as always for sharing information on clinical trials!!!

@GloHo Thank you for bringing this study to our attention. Its always nice to have a short cut. 

I have my 6 month scan next month and hope / expect to be platinum sensitive as my CA 125 remains normal. I recently read a paper suggesting that the use of PARP inhibitors has blurred the 6 month definition by delaying progression. Patients who previously would have been deemed resistant are now classified as sensitive. 

Welcome to the group Pat. I love the Copper Kettle in Tera Cotta.

@mcb thanks for sharing this information. To be honest I had not to this point read information on platinum sensitive vs. resistant so appreciate this information. Fingers crossed all is well with your CT scan however the CA125 low levels are always great to have!

@mcb

Good luck on your scan next month 🤞.

Thanks for sharing this info. Very interesting  and promising.  

Thank you for sharing this.  I too am carboplatain reactive, but my cancer is low grade so I don't qualify for this study.

I am presently in another study called Personalized Onco Genomic, available in BC i know for sure. I am on a treatment through this study, with a medication that should fight the specific anomaly they found in my cancer by doing a DNA panel of one of my lesions. It looks like this medication is doing something, as shown on my last CT scan.  

The side effects of the med I am on are challenging, so we adjusted the dose so I can tolerate it  Keeoing my fingers crossed!

@Sylviequebecbc  Checking in to see how your treatment is going and your symptoms. Are they being managed or are you having to tweak some things? How have you been feeling being on it? I have my fingers crossed for you.  Like you, I am LGSC. Nothing is available for me so in the meantime it is day to day living. My cancer numbers continue to climb and I monitor symptoms and eating as the issues come up to hopefully avoid partial bowel blockages.  How have you been doing in that department? How is your eating going? 

@Strongwoman  thank you for your post! I am doing ok. The side effects from the medication are much better now that I am on a lower dose. I haven't had a bowel episode since last November, so that is a relief.  My appetite is diminished,  I get full fast, so I have to eat small meals more often, but really, I don't feel hungry most of the time, so I am not eating as much as I could. 

My last scan showed some improvement on some level, stable lesions, and some grew. My CA 125 is dropping, from 1700's to 1500's in one month. So we think the med is doing something.  She wants me to stay on it a bit longer before we switch to the 2nd med that came up in my study profile.  Hopefully I won't get too sick before. She explained that the medications might work on the "mother cancer cells" but not on the clone cells, but we can't know yet since I haven't been on this med very long. 

So time will tell. In the meantime, I am adjusting to my new normal, I won't be hiking up hills this summer, I am very thankful for my electric bicycle,  I can get around without much effort. I can still do some housework,  my daughter helps with the big jobs,  and others too. I have started water color painting, it is relaxing.  

So all in all, I am coping fairly well, but I have my moments! 

Sending you warm hugs, keep me posted ❤️