English Community

Hello Teal sisters,

@GloHO, thank you for informing us about clinical trials.

I have recently watched a movie "of medicine and miracles" telling the story of the development of CART-T cell therapy in a dramatic way based on the scientist vision and the story of the first girl with ALL who responded to it.

You can rent or buy it on you-tube: Of Medicine and Miracles

YouTube		remove preview
Of Medicine and Miracles At the age of six, Emily Whitehead was diagnosed with leukemia and the lives of her and her parents were suddenly thrust into uncertainty. Through bracingly honest interviews and home videos, Of Medicine and Miracles details her family's experience bouncing from hospital to hospital, trying to stay hopeful amidst hopelessness, and their fateful correspondence with a doctor whose research could hold the key to her survival. View this on YouTube >

It is absolutely inspirational and creates the feeling of hope. To never give up. Also it nicely explains the development of CART T-cell therapy. 

Carl June's wife (the scientist who developed CART T-cells) actually died of ovarian cancer.. In the movie, he says that he experimentally treated her. While she died of organ complications, an autopsy that was done did no longer identify cancer cells.

It is not there yet for ovarian cancer, but it might be a possibility for the future

https://www.pennmedicine.org/news/news-blog/2023/august/carl-june-on-the-boundless-potential-of-car-t-cell-therapy#:~:text=One%20of%20the%20best%20examples,%2C%20MD%2C%20the%20Richard%20W.

@Tanja

What an amazing story! I have not done a lot of research on CAR-T cell therapy…probably because I haven't seen any clinical trials for OC yet. Let's hope they get this to trials for OC soon. 

@GloHo the really new staff comes under “ treating solid tumor” phase 1 and 2. But agree, best to wait until it comes into OC field and they are coming. I remember that Buffalo told me about a CART T-cell study for serious HGOC that they are currently doing, I was disappointed that I couldn’t participate as I am clear cell. But I think it is good to watch out for it. Problem in OC if the difficult to penetrate microenvironment of the tumor. Several researchers are trying to improve the methods. Another issues, is the scalability. Can you really produce individualized CART T-cells for everybody in need? Here, I just read that scientist think about using T-cell from healthy people and genetically engineer them to be tolerated by others. So, lots of good ideas out there.

@Tanja

Amazing stuff they're doing! Thanks for the info on Buffalo, I'll have to look it up and see what it's about. 

@GloHo the really new staff comes under “ treating solid tumor” phase 1 and 2. But agree, best to wait until it comes into OC field and they are coming. I remember that Buffalo told me about a CART T-cell study for serious HGOC that they are currently doing, I was disappointed that I couldn’t participate as I am clear cell. But I think it is good to watch out for it. Problem in OC if the difficult to penetrate microenvironment of the tumor. Several researchers are trying to improve the methods. Another issues, is the scalability. Can you really produce individualized CART T-cells for everybody in need? Here, I just read that scientist think about using T-cell from healthy people and genetically engineer them to be tolerated by others. So, lots of good ideas out there.