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Stage 3C HGSC, platinum-resistant with early recurrence after first-line treatment (was NED for 3 months). On weekly Paclitaxel + bi-weekly Bevacizumab since Aug 27, 2025.

I did skip Paclitaxel + Beva on Nov 19, Paclitaxel on Dec 24, and Beva only on Dec 31 due to port placement and clot risk. Normal schedule resumed Jan 7.

CT scan Dec 22 showed slight improvement compared to Oct 14.

Port placed Dec 30, 2025

CA-125:

Dec 30 (pre-surgery): 18.8

Jan 6: 22.4

Jan 28: 51.6

I initially thought the rise might be port-related inflammation, but it’s been a month now and the increase feels significant while still on treatment.

Has anyone else had a CA-125 rise like this after port placement or after skipping a few treatments while on chemo/Beva? Did it turn out to be inflammation or progression?

Hi @Cole 

I can't speak to having anything "port" related however I did have a rise in my CA-125 when I had a chest infection. It's a measure so sensitive to any inflammation elsewhere in your body that it can be frustrating when it rises. Were you able to speak to your medical team for any information? Normally they'd be looking for other markers in your labs.

#Treatmentandsideeffects