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Hi ,saw the oncologist today after completing 3rd line standard chemo for HGSO stage 4 and am now platinum resistant . Chemo worked on some tumors but no effect on the mass growingon my liver. My ca 125 increased throughout treatment but has doubled from last treatment 100 to 204 in the 6 weeks since treatment ended.

After much discussion decision was made to try avastin/ caelyx bi weekly. Im still on the fence regarding continuing with treatment at all.

Has anyone had this combo and if so how was it tolerated?

Thanks in advance. 

Alexson

I'm sorry you're going through this, it's such a difficult place to be. I understand being on the fence about continuing treatment. I'm platinum resistant. I've been on bi weekly Avastin with weekly Paclitaxel since Aug 27, 2025 and found it very manageable overall. Everyone is different.Whatever you decide is the right choice for you. Sending strength, you're not alone. Keep us posted  🩵 

I would say never ever give up treatment.  You have no idea what will work and how well. They put me on Avastin and Taxol 3 1/2 years ago and I'm still on it - cancer is stable to everyone's surprise. They thought I would have 6-12 months - I've had an extra 3.5 years so far!  Please check out 'Chris Beat Cancer' online and Jane McClellands Book 'How To Starve Cancer'.  Those sites and books are my 'do what I can to help my body survive this cancer and this  chemo' sources for great ideas on supplements and other treatments that might help.  Honestly, they have likely saved my life.  I re-read all of Chris Wark's stuff this week as I wait for my Avastin to be added back in after a break for a bowel obstruction.   I am taking supplements to help my body NOT allow the cancer to grow.  I cross reference all supplements with possible drug interactions.  I look at PubMed research for any studies showing if any of them work.  I step outside the box when I figure I have nothing to lose.  For example, when first told 6-12 months to live, I used CBD/THC suppositories and they brought my CA 125 down from 130's to 80 something.  I have tried a whole bunch of stuff that isn't 'standard of care' which I refer to as 'substandard of care'.  In Europe they are much more open to alternative therapies; here you have to say nothing to your oncologist (after doing your own research for safety and efficacy of course) or say something and because they don't know about it or aren't 'allowed' to advise patients on natural remedies they will likely say don't do it.  Well, my attitude is, its my body and my fight and I'll do what the hell I want.  Like I said, I research the hell out of anything I'm considering. My oncologist always tells me, "Your cancer isn't behaving normally and I don't know why this combo still works for you." And I think, "Well, aren't you curious as to what I am doing to make it this far?"  But I just keep my mouth shut and carry on. Hope this gives you some hope.  The most important part of my message is to do your own research before taking or doing anything 'outside the box'. Good luck!

Free this weekend - some really good stuff on fighting the beast.  Module  9 on teas, supplements etc very very informative but they are all good. 

https://sq1.chrisbeatcancer.com/10day-screening-live

Hi @Alexson ... I am sorry to hear your current diagnosis. I can only imagine the stress you may be experiencing. I cannot speak to the avastin / caelyx treatment however I did search this site and it appears there were quite a few Teal Sisters who have used this combination. I also searched "platinum resistant" on this site and again there were quite a few posts. Perhaps there will be something you can glean from there that will provide some information and/or raise questions you can ask. It sounds like your oncologist may have provided a lot of information. You clearly have more questions so I hope the information on this site can address some of those questions and/or help identify questions to go back and ask your oncologist. How you choose to proceed will be a personal choice and as @Cole said, whatever you decide will be the right choice for you. I appreciate the information @BellaDonna1959 has shared as well.

There is also a Teal Tea coming up in March. I will try to find the date and send that information to you. Perhaps there will be some women who join that session who could speak to Avastin/Caelyx. 

I hope you find answers that will help with your decision. Will be thinking of you. Please keep us posted with your journey.

#Treatmentandsideeffects

Hi @Alexson .... the registration for the March 24th Teal Tea is in the "Upcoming Events" section of the homepage of OVdialogue.  I'm not sure your age however there is a separate one for "young people" with ovarian cancer. Both of these sessions are listed. The April one's are also there too.

https://ovdialogue.ovariancanada.org/home/memberhome