English Community

 View Only

Log in or create an account to engage on OVdialogue. 

  • 1.  Abraxane (aka nanoparticle albumin-bound paclitaxel)

    Posted 11 days ago

    Good morning Teal Sisters,

    I see that word is getting out about Abraxane, an alternative for those who have experienced a severe reaction to Paclitaxel.  After my initial cancer diagnosis mid-2021 I was prescribed 6 cycles of Paclitaxel and Carboplatin.  During my first infusion I had an immediate negative reaction - stage 3 anaphylaxis.  Paclitaxel was stopped and for subsequent chemo cycles I was admitted to hospital for at least one, if not two, overnights for a very slow infusion over 12 hours.  Thankfully there were no further negative experiences, but I worry about the potential damage caused by the extended time period that the drug was being administered.

    More recently my Oncologist removed a 10 cm mass on left ovary.  With pathology indicating cancer recurrence, he has recommended me for a further 6 cycles of chemo.  Due to my severe reaction 4 years ago I am "eligible" for Abraxane in place of Paclitaxel.  My first cycle is Wednesday, May 28th.  My fingers are crossed that all goes well, as the infusion period is 30 minutes and can be administered as a day patient.

    I have also dusted off the two Ovarian Cancer Canada guides - By Your Side and Still By Your Side.

    I am very grateful for everyone in the medical and research community, as well as my supporters near and far.  Together we are making things better for all women who are diagnosed with this disease.

    Be strong!

    - Wendy



  • 2.  RE: Abraxane (aka nanoparticle albumin-bound paclitaxel)

    Posted 10 days ago

    WEMK  What an awful experience you had four years ago.   I had a reaction for the very first one in 2020, but not nearly as severe as yours.  Extra doses of steroids and Benadryl settled it down, the dosage was slowed and I finished that treatment.  The next five went without a problem.

    This time, the plan was for the dosage to be slowed and it went fine for the first treatment, but on Thursday, I recognized the first sensation right away and called the nurse.  Abraxane wasn't available in 2020, according to the pharmacist, so this time there is an alternative and I went back on Friday for that.  It actually took 45 minutes for the infusion and, then, an hour for the Carboplatin, which also has to be administered more slowly, since this is my 3rd time taking it.

    The after effects seem to be about the same, except that the pre-meds are one steroid and 2 anti-nausea tablets so I wasn't feeling as loopy when I was done Friday afternoon as I get on Benadryl.  I have my 'preventative' collection on my night table -- Tylenol, Tums, Imodium, and the anti-nausea medication prescribed by the pharmacist.  So far, so good.

    Good luck with it all, Wendy.  




  • 3.  RE: Abraxane (aka nanoparticle albumin-bound paclitaxel)

    Posted 10 days ago

    Thanks for your encouragement GGail.  All the best for a positive outcome and an easy journey.




  • 4.  RE: Abraxane (aka nanoparticle albumin-bound paclitaxel)

    Posted 10 days ago
    This is also called nab-paclitaxel.
    I have just finished 8 treatments without very little side effects so hope it works for you. My CA-125 has come down almost 200 points in 1 month so hoping it is doing its job.
    Wishing you good luck on this new treatment.

    Sent from my iPad




  • 5.  RE: Abraxane (aka nanoparticle albumin-bound paclitaxel)

    Posted 10 days ago

    Hi Wendy,

    My name is Cailey Crawford and I'm the VP, Programs and Policy at OCC. I am so sorry to read about your recurrence and the challenges you've had with chemo. You mentioned that you were dusting off your copies of By Your Side and Still By Your Side. I wanted to let you know that we updated our guides into one comprehensive guide last year and you can order your free copy at this link: https://ovariancanada.org/resources/support-resources 

    I'm sorry to hear about what you have been going through and like you, my fingers are also crossed that all goes well.

    Take good care,

    Cailey




  • 6.  RE: Abraxane (aka nanoparticle albumin-bound paclitaxel)

    Posted 8 days ago

    Hi Wendy, 

    On my second infusion of paclitaxel I experienced a stage 4 anaphylaxis reaction. It was a terrifying though, admittedly, I don't remember most of it, just little flashes. 

    After that reaction, I was immediately switched to abraxane for my remaining courses. It was great having a reduced infusion time but as it is nab-paclitaxel (just lacking all the fillers and additives in paclitaxel) the side effects were similar. 

    I did learn that it is considered to be more effective, so I'll take that as a bonus. 

    Thankfully, I've been NED for 2.5 years.

    All my best for you! 
    Lisa




Log in or create an account to engage on OVdialogue.