@DiamondGoddessYYC. I am not doing immune therapy right now- no need yet. I am Clear Cell (5% of all OC, more in Asia) diagnosed Jan 2023, R0 surgery in Feb and the 6 cycle Carbo/Pacli + Beva, interrupted by acute bowel obstruction - adhesion. Recurrence of small tumor in spleen in Feb 2024 after 7months. Surgery in July 24 with splenectomy - no other tumor site. Another 6 cycle of Carbo/Pac, finished in Dec 24. So far tumor free. Argued for another Bevacizumab round which I am still getting. My argument is that serous cell people get PARPinh as maintenance therapy but clear cell patients get nothing?
With recurrence I got nervous and went for 2nd opinion to Buffalo. They had several clinical trials based on immune therapy which they were convinced was the next best treatment option for clear cell- ideally in combination - 2 immune drugs or with Bevacizumab. Then I decided to go for surgery which was the right choice. But if I have another recurrence I will look for a clinical study with immune therapy or try to get immune therapy in clinic.
Has your tumor been examined for genetic mutations? There are several pathways that can be defect in clear cells and for which there are specific treatment strategies. Unfortunately, I have none of these positive. And then you can also be eligible for elahere once it is approved as long as you have positive folate alpha receptor on your Tumor.
But it could be that also radiation works - I have no experience and knowledge about that.
Sent from my iPhone
Original Message:
Sent: 6/27/2025 5:03:00 PM
From: DiamondGoddessYYC
Subject: RE: Radiation or Lymph Node experiences?
Thank you @Tanja!
I will send this in to my Gyne-Onc to ask him about this.
Hope you're doing ok?
Appreciate your insights
Original Message:
Sent: 06-26-2025 19:06
From: Tanja
Subject: Radiation or Lymph Node experiences?
@DiamondGoddessYYC - as clear cell patient you may want to discuss possibility and effectiveness of immune therapy with your oncologist - PD-1 antagonists such as pembrolizumab. While these drugs are not really successful in ovarian cancer, all trials have been mainly done in serous cell It looks like that clear cell better responds. Just an idea.
Original Message:
Sent: 6/25/2025 10:43:00 PM
From: DiamondGoddessYYC
Subject: RE: Radiation or Lymph Node experiences?
Hello
I did a search about radiation in the discussions and it seems yours @Readersmaven is the most recent one I found.
Unfortunately I see no one replied :(
I have a consult July 8, 2025 for Radiation consult for para-aortic lymph node where the Clear Cell Ovarian Cancer has returned in my body.
What happened for you 4 years ago @Readersmaven?
Original Message:
Sent: 02-08-2021 16:39
From: Readersmaven
Subject: Radiation or Lymph Node experiences?
I'm looking for insight and experiences from anyone who has recently had radiation treatments. I'm having a phone consult this week with a radiation oncologist to discuss this as my recent CT scan shows a growing lymph node in pelvic area.
Dx fall of 2019, chemo from Dec to May 2020, debulking surgery March 2020, declared NED and have been on lynparza since. CA125 has been climbing, it's now over 700.
Worst of it is that I feel great, so bit of a struggle with this.
Thx!