Hi @deebus52, I'd like to know how the trial is going for you so far. My mom has high-grade serous OC, stage IV, BRCA negative. Responded to 4 carbo/taxol cycles very well the first time, had debulking surgery, had 3 more chemos and declared NED, but after 7 months we found out she had a recurrence, with mets to adrenal gland. Neither carbo/taxol nor caelyx/avastin worked on the recurrence, it just kept on growing, and adrenal biopsy was inconclusive. She now she has another metastasis on her chest wall. Biopsy of that mass shows it's now carcinosarcoma (even more aggressive). Her oncologist suggested a clinical trial before trying third- or fourth-line chemo options (weekly taxol or gemcitabine).
Today we took my mom to Princess Margaret and she was offered a trial similar to yours, but with the addition of Keytruda to the DPX-Survivac/low-dose cyclophosphamide combo. She is not sure what to do yet... it's all so overwhelming for her. It feels like a gamble... go with an known/tested chemo option that has a 20% response rate, or go with something completely new that shows promise but that we don't know much about. It would be good to know if any of these immunotherapy drugs on their own, or a combination of them, have better results.