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Somatic whole gene deletion (copy number loss) and PARPi response

mcb
mcb
in Genetics

I have HGSC, stage 4. I do not carry either BRCA genetic mutation. However, the pathology report on the tumors that were removed show that 40-50% of the cells have a deletion of the entire BRCA1 gene. They could not determine if it is hetero or homozygous. There is also a deletion of the BRCA2 gene which is heterozygous.

It is enough that the surgeon feels I am a good candidate for PARPi once chemo therapy is done.

I'm wondering if anyone here has had this experience and how did you do on that treatment?

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