I have followed up about Lynparza and platinum resistant ovarian cancer. As I suspected, it is not available. Health Canada has approved this drug only for the "maintenance treatment of adult patients with platinum-sensitiverelapsed
(PSR) BRCA-mutated (germline or
somatic) high grade serous epithelial ovarian, fallopian
tube or primary peritoneal cancer who are in response (complete response or partial
response) to platinum-based chemotherapy.(Platinum-sensitive
relapse is defined as disease progression occurring at least 6 months following completion of platinum chemotherapy.)"
Unfortunately, this means that Lynparza is not an option if the cancer is platinum resistant. I am not sure exactly where you live but here is a link to the Princess Margaret website that lists some clinical trials that you may qualify for. It is very technical information so I would ask your doctor to review these and see if one of them is appropriate for you.
I would also ask your doctor what clinical trials are available at the centre where you are currently being treated.
I'm sorry I don't have better news for you!
Hello to the group!i was diagnosed with Stage 3c high-grade serous Ovarian Cancer in January 2014. After surgery, I did 6 rounds of Paclitaxol by IV and 4 rounds of Cistplatnin by IP followed by 2 rounds of Carboplatnin by IV when my IP port failed. I am BRCA 1 positive. Following treatment I was declared clear of visible cancer and qualified for the SOLO 1 clinical trial. For 2 years I followed the daily regimen of the trial, didn't eat a grapefruit or marmalade, and saw my oncology team at least every 3 months. Imodium was my constant companion and I took iron supplements to keep my iron looking good. At the end of 2 years I had to come off the drug as per the study. That was September 2016. Throughout the study period my CA 125 remained stable between 8-12 and my many CT scans were clear. In November 2016, my CA125 was 16, and the slow and steady increase began. I have been unblinded from the study and we now know that I was on the medication. While Olaparib did not cure me, it held my disease at the microscopic level and kept it stable. I am now being treated for recurrence and after treatment hope to again be able to be treated with Olaparib. I tell you all of this to say I have lived on this medication successfully for 2 years. All through this time I worked full-time, became a doting grandmother and led an active and engaged life. There were side affects that I found manageable through medication and lifestyle choices. There seemed to be a bit of a cycle to my side effects - the better I took care of myself, the less they intruded. I experienced fatigue (diet, naps, lots of water); low grade nausea; diarrhea (diet changes, Imodium and water); mouth sores; increased chemo brain/forgetfulness; leg cramps (magnesium supplement); low iron (pumpkin seeds and supplements). At the end of the 2 years I was staring to feel like I knew what normal was again. I found the routine and pattern that worked for me while taking this drug. For those of you who decide to try it, I sincerely hope that you are able to find the balance that works for you.
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