I've recently completed first-line chemo for stage 3b carcinosarcoma, and was looking for anything that might reduce or delay recurrence. I am BRCA-negative, so a PARP inhibitor may not be of any benefit to me. My gyne-onc referred me to the Princess Margaret Cancer Centre in Toronto and they suggested that I might be eligible to participate in the phase 3 ATHENA trial. It's a bit complicated, but basically this trial is a 4-arm double-blinded trial of a combination of rucaparib (a PARP inhibitor) and nivolumab (immunotherapy - a checkpoint inhibitor).
The process seems to be quite onerous - they tell me I would have to stay in the Toronto area (I live in Ottawa) for the first couple of months of treatment, and then would have to go there for up to 3 nights every month for about 2 years. There are many potential side effects, some of which have very low probability of occurring but very high consequence if they do - things like heart inflammation, brain inflammation, kidney failure, etc. And of course, there's a chance of being in the placebo group and going through all the hassle for nothing.
I have to make a decision really soon, and I'd love to hear if anyone else is in this trial or has considered it.