Chemotherapy symptoms, combined carboplatin/paclitaxel

I was diagnosed in 2015 with Stage iv high grade serous ovarian cancer.  I went on a dose dense weekly chemo protocol, had debulking surgery, then 2 more cycles of chemo.  I was pleasantly surprised that I had no major adverse reactions to chemo, and had 2 1/2 years of remission before recurrence. A week ago I had my first chemo session with large dose of paclitaxel and carboplatin (GOOVCTR) to be administered every 3 weeks.  The side effects of this protocol are far more serious, because of the joint and nerve pain I am still experiencing a week after the treatment.  It feels like I am walking on pins and needles.  I am concerned that the nerve damage could possibly be permanent after 6 rounds on this chemo.  Has anyone experienced this, and if so, how are you doing after treatment?  The fatigue and slight nausea I can handle, but nerve pain not so much.  Any information would be appreciated

Comments

  • I should have read the dialogue on neuropathy before posting my request, but I am new at this, and I now know that a lot of people are experiencing it.  This OVdialogue is going to be very helpful to me.
  • [email protected],
    There is a lot of useful information here, but never hesitate to ask questions at any time.

    I had neuropathy combined with hand and foot syndrome with my last round of Carboplatin /Paclitaxel. We switched to Docetaxel and reduced the dosage.   
    I found much of the neuropathy  and nail issues disappeared after a 8 week chemo break following an allergic reaction to the Carboplatin. 
     I am now back on Cisplatin with Docetaxel and I have an increase in neuropathy and nail pain already after 1 cycle.  Will see how it goes for the next two cycles before I am reassessed as to the effectiveness of this regime on my disease. It might just be a side effect I have to tolerate.
  • Thank you, @midcanada, I will be discussing the issue with my oncologist again to see if there are other options.
  • Welcome @smm70 - yes, that is best to advise your DR team of your concerns and the neuropathy as they will be looking out for you. 
  • @smm70, I also had the CARBOPLATIN/PACLITAXEL , 6 treatments, 3 weeks apart.  This was at the beginning of 2017. While the IV was in, I had extremely annoying restless legs, so sometimes I could not stay in the chair, I had to stand and stretch.  Apparently though, that was due to the steroid pre-med. Bone joint pain?  I had a bit of that and I just took the acetaminophen that had been prescribed. By the time I got to session, 4, 5 and 6, I was extremely exhausted around day 4, 5 after treatment. The tingly feet didn't really start until 2 weeks after chemo was all finished. It got a bit worse over 3 months, and has stayed at the same level now for a year.  The doc said it might last 2 years. 
      I have a sort of 'funny story,' but I'll see if I can post it in the neuropathy section. 
  • I was diagnosed last August, had surgery in September the surgeon said stage 2, the oncologist said stage 3, started chemo in November..6rounds 3wks apart on paclitaxel/carboplatin. The first round after experiencing restless legs from the premeds would last about4hrs..it was more annoying than anything else...then I had a reaction to the paclitaxel, so I had increased doses of premeds each time after... I got bone aches in my legs about 2days later that lasted about 4days, I found walking helped ease the pain. other than that just the usual tiredness and hair loss which I didn’t care about, it has grown back in. 
  • Hello @nell1261 - welcome to the chat site. Thank you for sharing your update. Are you now finished the chemo and how are you feeling?
    You are welcome to post your story on your bio page if you like as well.
    We try to meet by live chat on Tuesdays at 7:00 PMCST if you are around to join us. 
    I'll also direct message you. 
  • Hi, my name is stef. My sister has just been diagnosed with high grade serous ovarian cancer. I am really worried
  • She is stage 3a. She had a hystectomy on July 10... First chemo was on Aug 8. She is super weak. Anyone that can shed some light or their experience would be so nice
  • Hello @Scarstef - we are sorry to hear about your sister's recent diagnosis. Hope you will find much support here.

    There are 4 pages of topics so you may want to take some time to view the past posts to see the experiences/comments  the chat participants have shared. There are also previously recorded webinars on the main site which I have found most helpful. You can find one here on coping with treatment / side effects:

    I'll also private message you.
  • Thanks so much flower girl. My sister is going through alot bc of chemo.  Constipated, depressed, nausea.  It's just frightening.  I'm so scared 
  • Hello again @Scarstef.. hoping for her that the side effects will lessen soon... the DR team can offer her some solutions to cope. And yes, it is important for her and you to get some support for the emotional effects too.
  • Hi I just had my first chemo on August 7th and it took about 1 week and half for the joint pain to be bareable and I have had all different other side effects.  Is there anything you can recommend like supplements or medications that would help with pain management... thank you 😊 
  • Nancy1Nancy1
    edited August 26
    Hi my name is Nancy.....I was first diagnosed back in Nov 2004 at the age of 43...had surgery and 6 rounds of carbo/taxil.  First recurrence happened 2012.  Had a second surgeryearly 2013.  Next recurrence late 2013....had 51/2 rounds of carbo/taxil again through 2014 but could not complete the last round in the hospital due to severe reaction.  Next recurrence late 2015.  Started Kalex end of Mar 2016 for 3 rounds but had such as severe reaction could not take anymore.  Switched to Doxirubin for 6 rounds then drug stopped working.  Had a break until May 2017 then did cisplatin/Paxil for 6 rounds in the hospital.......had the pain and completely numb feet and hand and pins and needles.  Happy to say that the majority of the neuropathy cleared up after about 6 months.   I have just started Lynparza Aug 2018 and I’m BRCA negative.
  • Hello @Nancy1 - welcome to the chat site. Thank you so much for sharing all the issues you have dealt with so far... good to hear they are looking after you. It is great to hear that the neuropathy has also changed for you.
    We invite you to review the past topics on the site and hope you will find much support from everyone.
    I'll also direct connect with you.
  • @Nancy1 ; You have incredible perseverance and determination.  Thank you for telling your story.  Good luck. 
  • Hello Nancy1.  I am sending good energy your way. You have a lot of courage and determination. Keep in touch.

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