Has anyone else been on megestrol as a maintenance drug? I was on a dose of 160 mg a day for five years. In December, the doctor at the cancer centre told me that I could quit and didn’t refill my prescription. After a week or two I began to lose my appetite and feel nauseous, I also felt extremely fatigued with flu-like symptoms. Now I’ve resumed taking megestrol, but they are lowering my dose to 80 mg with the intention of slowly weaning me off of it. Has anyone else experienced withdrawal or seriously negative side effects from this drug?